Application of stem cells in guided bone regeneration
نویسندگان
چکیده
Modern medicine allows us to study and develop materials methods of restorative treatment that would be based on the immunological mechanisms bone repair. One promising directions in guided regeneration is use mesenchymal stem cells. Interest MSCs associated with their ability regulate inflammatory process, directly participate formation new structures, thereby providing a physiological repair process. The effector impact process due form specific microenvironment. Low expression MHC-II CD80/CD86, production PGE2 NO determines low immunoconflict, TGF-b1, IDO IL-10 has an immunomodulating effect. differentiate into osteogenic phenotype accompanied synthesis ALP, BSP and, subsequently, Gla-protein OPN determine extracellular matrix its subsequent mineralization. This provided by action Runx2, which activates differentiation along pathway. These effects were taken as basis for development method atrophy. To accomplish task set, model tissue atrophy drug containing was developed, experimental conducted evaluate effectiveness developed methodology. As main criteria, data from clinical laboratory studies taken. Visual changes studied area account, compared similar atrophy, parameters complete blood count (CBC) evaluated. performed capable fully recreating conditions processes, taking account optimization body’s immune reactions without additional external influence, obtain predictable controllable results.
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ژورنال
عنوان ژورنال: ??????????? ???????????
سال: 2023
ISSN: ['2409-5788']
DOI: https://doi.org/10.15789/1563-0625-aos-2724